Organic disulfides
Selleck Chemical LLC NX-2127-E1381-25MG
NX-2127 is a unique potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells
eMolecules SPDP-PEG-Succinimidyl Valerate, MW 5,000 | Broadpharm |455.540 | C19H25N3O6S2 | 0.000 | O=C(CCSSc1ccccn1)NCCOCCCCC(=O)ON1C(=O)CCC1=O | 500mg | 627958335
SPDP-PEG-Succinimidyl Valerate, MW 5,000 | Broadpharm |455.540 | C19H25N3O6S2 | 0.000 | O=C(CCSSc1ccccn1)NCCOCCCCC(=O)ON1C(=O)CCC1=O | 500mg | 627958335
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 500 MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (Btk). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. In vivo, it demonstrates potent degradation of BTK in cynomolgus monkeys and leads to superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice.
- Inhibits proliferation of BTKC481S mutant TMD8 cells
- Catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
- Stimulates T cell activation and increases IL-2 production
- Demonstrates potent degradation of BTK in cynomolgus monkeys
- Leads to superior tumor growth inhibition in xenograft models in mice
Medchemexpress LLC PROTAC degrader targeting Bruton's tyrosine kinase (BTK) | 2416131-46-7 | 99.7% | 719.83 | C39H45N9O5 | 10 MG
NX-2127 is an orally bioavailable PROTAC degrader that targets Bruton's tyrosine kinase (BTK). It induces proteasomal degradation of BTK, shows activity against BTK C481S resistance mutants, degrades IKZF1 and IKZF3 transcription factors, and has demonstrated cellular and in vivo preclinical activity while promoting T cell activation and IL-2 production.
- Orally bioavailable PROTAC degrader of BTK.
- Induces proteasomal degradation of BTK and reduces BTK signaling.
- Active against BTK C481S resistance mutants in cellular models.
- Degrades IKZF1 and IKZF3, providing immunomodulatory effects.
- Stimulates T cell activation and increases IL-2 production in primary human T cells.
- Demonstrated efficacy in preclinical in vivo models.
Chem-Impex International, Inc. 3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester | 68181-17-9 | MFCD00009636 | 250MG
3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester, 68181-17-9, MFCD00009636, 250MG
Medchemexpress LLC HY-W011690 100mg Medchemexpress, L-Homocystine CAS:626-72-2 Purity:>98%
Medchemexpress, HY-W011690 100mg L-Homocystine CAS:626-72-2 L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 1,2-Benzenedicarboxylic acid, 1,2-dicyclohexyl ester | 84-61-7 | ≥97.0% | 330.42 | 25 G
Dicyclohexyl phthalate (DCHP) can be used as a plasticizer. It is a biological material or organic compound widely used in life science research.
- Can be used as a plasticizer.
- A biological material or organic compound widely used in life science research.
Medchemexpress LLC Diphenyl disulfide | 882-33-7 | MFCD00003065 | 100.0% | 218.35 g/mol | C12H10S2 | 1g
Diphenyl disulfide is an endogenous metabolite Diphenyl disulfide is a pharmaceutical intermediate Diphenyl disulfide can be coupled with aryl iodide to synthesize asymmetric aryl sulfide[1][2]
Medchemexpress LLC Bis(2-methyl-3-furyl)disulfide | 28588-75-2 | 98.4% | 226.31 | 500 MG
Bis(2-methyl-3-furyl)disulfide, compound (2), is a flavoring compound designed to enhance the natural, fresh, and milk-rich feeling of milk-related products. It is for research use only and not sold to patients.
- Enhances natural feeling of milk-related products.
- Enhances fresh feeling of milk-related products.
- Enhances milk-rich feeling of milk-related products.
Chem-Impex International, Inc. 3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester | 68181-17-9 | MFCD00009636 | 100MG
3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester, 68181-17-9, MFCD00009636, 100MG
TARGETMOL CHEMICALS INC NX-2127 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells. Purity 98.11%
Sigma Aldrich Fine Chemicals Biosciences Propyl disulfide 97 FG5KG
Propyl disulfide is a volatile flavor compound mainly found in allium species such as onion chive and scallions.
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 25 MG
NX-2127 is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (BTK). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) and stimulates T cell activation.
- Inhibits proliferation of BTK-C481S mutant TMD8 cells
- Catalyzes degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
- Stimulates T cell activation and increases IL-2 production
- Potently degrades BTK in cynomolgus monkeys in vivo
- Leads to dose-proportional exposure in plasma
- Results in superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice